![]() GnRH-dependent precocious puberty, often called central precocious puberty (CPP), is usually treated with GnRH analogs. ![]() The etiologies of precocious puberty may be subdivided into GnRH-dependent and GnRH-independent causes. The regulation of kisspeptin secretion is not well understood, but neurokinin B and dynorphin provide autocrine regulation. The earliest identified neuroendocrine change in early puberty thus far is increased kisspeptin secretion from the arcuate nucleus and the anteroventral paraventricular nucleus of the hypothalamus. Precocious puberty is a common problem affecting up to 29 per 100 000 girls per year.
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